The maturation of all blood cells occurs within the microenvironment of the bone marrow, a soft tissue that fills the cavities of the bones, composed of a network of extracellular matrix components and intercellular fluids generated by pressure gradients from the vascular system that facilitate the process of hematopoiesis.

Bacterial keratitis (BK) is an ocular infection which constitutes the majority of infectious keratitis cases all around the world, and has estimated about 2.5-799 cases per 0.1 million population per year.

Skeletal muscle tissue (SMT) is the largest organ by mass in the human body and is critical for locomotion, posture, respiration, physiology, and energy homeostasis. Genetic or acquired diseases, as well as damage and aging can make this organ dysfunctional and cause significant impairment in the quality of life and human health.

Knee menisci are macro-structurally semilunar wedges and act as a congruent cushion between the femoral condyle and tibial plateau. Meniscal tissue injuries and tears caused by sports injuries, old age and accidents are a major cause of pain and discomfort among various population groups.

The main valvular heart diseases (VHDs), rheumatic heart diseases affect around 41 million people worldwide. VHDs can reduce the quality of life, physical functionality and sometimes cause sudden death. 

Non-invasive technique allows screening of thousands of tumor organoids at the level of individual cell populations, including those from which drug resistance arises.